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Image Search Results
Journal: Transplantation
Article Title: Urinary TIMP-2 Predicts the Presence and Duration of Delayed Graft Function in Donation After Circulatory Death Kidney Transplant Recipients
doi: 10.1097/tp.0000000000002472
Figure Lengend Snippet: FIGURE 2. TIMP-2 and IGFBP7 values were significantly different for patients with and without fDGF. Median ± IQR of both TIMP-2 and IGFBP7 are plotted for patients with and without fDGF. TIMP-2 values were significantly higher for patients with fDGF as compared to patients without fDGF (A). This also applied for the IGFBP7 values (B). Interestingly, TIMP-2 values of all patients decreased in the first 10 days after transplantation, where as IGFBP7 values increased. fDGF, functionally defined delayed graft function; IGFBP7, insulin-like growth factor-binding protein 7; IQR, interquartile range; TIMP-2, tissue inhibitor of metalloproteinases-2.
Article Snippet: Urinary TIMP-2 and
Techniques: Transplantation Assay, Binding Assay
Journal: Transplantation
Article Title: Urinary TIMP-2 Predicts the Presence and Duration of Delayed Graft Function in Donation After Circulatory Death Kidney Transplant Recipients
doi: 10.1097/tp.0000000000002472
Figure Lengend Snippet: FIGURE 3. ROC curves of TIMP-2 and IGFBP7 in the prediction of fDGF and prolonged fDGF The absolute concentration of TIMP-2 on day 1 could adequately identify patients with fDGF, and this further improved in case TIMP-2 was corrected for osmolality (TIMP-2/ mOsm) (A). The concentration of IGFBP7 on day 1, on the other hand, showed only limited predictive value also when corrected for osmolality (IGFBP7/mOsm) (B). On day 10, both TIMP-2 and TIMP-2/mOsm could also adequately predict prolonged fDGF duration ≥21 days (C), whereas IGFBP7 and IGFBP7/mOsm could not (D). fDGF, functionally defined delayed graft function; IGFBP7, insulin-like growth factor-binding protein 7; ROC, receiver operating characteristic; TIMP-2, tissue inhibitor of metalloproteinases-2.
Article Snippet: Urinary TIMP-2 and
Techniques: Concentration Assay, Binding Assay
Journal: Transplantation
Article Title: Urinary TIMP-2 Predicts the Presence and Duration of Delayed Graft Function in Donation After Circulatory Death Kidney Transplant Recipients
doi: 10.1097/tp.0000000000002472
Figure Lengend Snippet: FIGURE 5. TIMP-2/mOsm and IGFBP7/mOsm in tertiles. Patients were divided into tertiles based on TIMP-2/mOsm and IGFBP7/ mOsm concentrations, and the percentage of patients with fDGF and prolonged fDGF in each tertile was calculated. On day 1, patients without fDGF predominantly grouped together in the tertile with the lowest values for TIMP-2/mOsm, (77%), whereas patients with fDGF (92%) were in the middle or highest tertile (A). For IGFBP7/mOsm, a comparable figure was seen, with slightly lower percentages (B). On day 10, patients with prolonged fDGF predominantly grouped together in the tertile with the highest TIMP-2/mOsm values (83.3%), and none had TIMP-2/mOsm values in the lowest tertile (C). In contrast, patients with prolonged fDGF did not group together according to their IGFBP7/mOsm values (D). fDGF, functionally defined delayed graft function; IGFBP7, insulin-like growth factor-binding protein 7; TIMP-2, tissue inhibitor of metalloproteinases-2.
Article Snippet: Urinary TIMP-2 and
Techniques: Binding Assay
Journal: EBioMedicine
Article Title: Three kinds of corneal host cells contribute differently to corneal neovascularization
doi: 10.1016/j.ebiom.2019.05.026
Figure Lengend Snippet: Neovascularization-related factors in corneal tissues identified by immunoblotting and ELISA. (a) Detection of MMP-2, fibronectin, COL8A2, CRYAA, COL12A1, laminin α5, galectin-8, neuropilin-2, Bcl-2, MMP-9, Bax, TIMP-2, TIMP-1, VEGF-A, CD31, VEGF-C, and beta-actin in corneal extracts by immunoblotting. C1-C5, vascularized corneal tissues of patients; N1-N3, normal corneal tissues. (b) Detection of MMP-2, TIMP-2, galectin-8, VEGF-C, VEGF-A, COL8A2, Bcl-2, MMP-9, total laminin, COL12A1, fibronectin, CD31, Bax, and neuropilin-2 in corneal extracts by ELISA. Values represent the mean ± SD. Vessel (+), vascularized corneal tissues of patients; Vessel (−), non-vascularized corneal tissues of patients; Normal, normal control corneal tissues. N = 33 for vessel (+) group; n = 21 for vessel (−) group; n = 9 for normal group.
Article Snippet: The ELISA kits used in this study include MMP-2 (ml058669; Mlbio, Shanghai, China),
Techniques: Western Blot, Enzyme-linked Immunosorbent Assay